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Prevention of Type I Diabetes and Recurrent ß-Cell Destruction of Transplanted Islets¹

Barbara Davis Center for Childhood Diabetes, University of Colorado Health Sciences Center, Denver, Colorado 80262

I. Introduction

II. Disease Pathogenesis

III. Disease Prediction

A. Genetic prediction

B. Immunological prediction

C. Metabolic prediction

IV. Prevention of Type I Diabetes

A. Trial design

B. Genetic prevention

C. Prevention: preautoimmunity

D. Prevention: postautoimmunity/prediabetes

E. New onset patients/prevention of further ß-cell destruction

F. Pancreas and islet cell transplantation/prevention of recurrent diabetes

G. Islet cell transplantation/prevention of ß-cell destruction

V. Conclusion