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Catch-up Growth

Department of Pediatrics, Leiden University Hospital, Leiden, The Netherlands

I. Introduction

II. Catch-up Growth: Theoretical Considerations

A. Definition

B. Catch-up growth vs. compensatory growth

C. Canalization

D. Catch-up growth vs. resumption of a normal height velocity

E. Types of catch-up growth

F. Assessment of duration and success of catch-up growth

III. Secondary Growth Disorders and Subsequent Catch-up Growth

A. The early studies

B. Malnutrition

C. Celiac disease

D. GH deficiency

E. Hypothyroidism

F. Corticosteroid excess

G. Intrauterine growth retardation (IUGR)

IV. Mechanisms Regulating Catch-up Growth

A. The neuroendocrine hypothesis

B. The growth plate hypothesis

V. Determinants of Normal Growth and Their Changes During Catch-up Growth

A. Introduction

B. The somatotrophic axis

C. The epiphyseal growth plate

VI. Concluding Remarks