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The Endocrine Effects of Nonhormonal Antineoplastic Therapy

Joint Baylor College of Medicine-The University of Texas M. D. Anderson Cancer Center Endocrinology Fellowship Program (S.-C.J.Y., A.C.C.); and Section of Endocrinology (R.V.-S., R.F.G.), Department of Medical Specialties, The University of Texas M. D. Anderson Cancer Center, Houston, Texas 77030

I. Introduction

II. Disorders of Glucose Metabolism

A. Diabetes mellitus

B. Glycosuria and ketonuria

III. Disorders of Free Water Clearance

A. Syndrome of inappropriate ADH (SIADH)

B. Nephrogenic diabetes insipidus

IV. Disorders of Mineral Metabolism

A. Hypocalcemia

B. Hypercalcemia

C. Hypomagnesemia

V. Metabolic Bone Diseases

A. Osteoporosis

B. Rickets or osteomalacia

VI. Thyroid Disorders

A. Serum thyroid hormone-binding protein abnormalities

B. Hypothyroidism

C. Thyrotoxicosis

D. Thyroid neoplasm

VII. Disorders of Lipid Metabolism

A. Hypertriglyceridemia

B. Hypercholesterolemia

VIII. Adrenal Dysfunction

A. Primary adrenal insufficiency

B. Secondary adrenal insufficiency

IX. Disorders of GH Secretion and Growth

A. GH deficiency

B. Growth retardation

X. Reproductive Dysfunction

A. Reproductive dysfunction due to hypothalamic-pituitary damage

B. Gonadal toxicity

XI. Prevention and Surveillance of Endocrine Side Effects

A. Pediatric screening

B. Adult screening.