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Insulin Resistance versus Insulin Deficiency in Non-Insulin-Dependent Diabetes Mellitus: Problems and Prospects

C.N.R. Institute of Clinical Physiology and Department of Internal Medicine, University of Pisa, 56126 Pisa, Italy

I. Introduction

II. Preliminary Issues

A. Prevalence of insulin resistance in NIDDM

B. Methodology

C. Source data

III. Insulin Resistance vs. Insulin Deficiency

A. High-risk conditions and predictors

B. The problem by mechanism

C. The genetic approach

IV. Summary

V. Insulin Resistance: The Cluster Concept

VI. Prospects