This Article Full Text Full Text (PDF) Purchase Article View Shopping Cart Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Copyright Permission Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Gerich, J. E. Search for Related Content PubMed PubMed Citation Articles by Gerich, J. E.

The Genetic Basis of Type 2 Diabetes Mellitus: Impaired Insulin Secretion versus Impaired Insulin Sensitivity

University of Rochester, School of Medicine and Dentistry, Departments of Medicine, Physiology, and Pharmacology, Rochester, New York 14642

I. Introduction

A. General considerations

B. Diabetogenic vs. diabetes-related genes

C. Secondary impairment of insulin secretion and insulin sensitivity

D. Insulin deficiency vs. impaired insulin secretion

E. Misinterpretation of the Oral Glucose Tolerance Test (OGTT)

II. Strategy

III. Studies in Genetically Predisposed Individuals with NGT

A. First-degree relatives (excluding twins)

B. Identical twins discordant for type 2 diabetes

IV. Prospective Studies of Individuals Before Development of Type 2 Diabetes

V. Studies of Normal Glucose-Tolerant Women with a History of Gestational Diabetes

VI. Reversibility of Insulin Resistance and Impaired Insulin Secretion by Therapeutic Interventions

VII. Are all Type 2 Diabetics Insulin Resistant?

VIII. Hypothesis for Pathogenesis of Type 2 Diabetes

IX. Summary and Conclusion