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Intratumoral Aromatase in Human Breast, Endometrial, and Ovarian Malignancies¹

Department of Pathology (H.S.), Tohoku University School of Medicine, Sendai 980-8575, Japan; and Division of Molecular Genetics (N.H.), Institute for Comprehensive Medical Science, Fujita Health University, Toyoake 470-1192, Japan

I. Introduction

II. Aromatase Cytochrome P450 and in Situ Estrogen Production

III. Aromatase in Breast Cancer

A. Introduction

B. Localization

C. Genetic regulation

D. Clinical and pathological correlation

E. Male breast cancer

IV. Aromatase in Endometrial Cancer

A. Introduction

B. Localization

C. Genetic regulation

D. Clinical and pathological correlation

V. Aromatase in Ovarian Cancer

A. Introduction

B. Localization

C. Genetic regulation

D. Clinical and pathological correlation

VI. Summary