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Endocrine Reviews 20 (2): 136-155
Copyright © 1999 by The Endocrine Society

The Molecular Pathogenesis of Corticotroph Tumors

P. L. M. Dahia1 and A. B. Grossman

Department of Endocrinology, St. Bartholomew’s Hospital, London EC1A 7BE, United Kingdom

I. Introduction
A. Origin of tumors: hypothalamus vs. pituitary
B. Clonality of pituitary tumors
II. Protooncogenes
III. Tumor Suppressor Genes
A. p53
B. p16/CDKN2/MTS1/INK4 and Rb1
C. p27/KIP1/CDKN4
D. MEN1
E. hZAC
F. NM23
G. Other tumor suppressor genes
IV. Specific Genes
A. Regulatory receptor genes
B. Cytokines and growth factors
C. Developmental genes
V. Miscellaneous
A. Other genes
B. Methylation
VI. Perspectives: Old and New Tools for Understanding Pituitary Pathogenesis
A. Transgenic/knockout animal models
VII. Conclusions






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Copyright © 1999 by The Endocrine Society