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Selective Estrogen Receptor Modulators: Clinical Spectrum¹

Clinical Research and Regional Bone Centers, Helen Hayes Hospital, New York State Department of Health, West Haverstraw, New York 10993

I. Introduction

II. Breast Effects

A. Women with primary breast cancer without metastases

B. Women with metastatic disease

C. Breast cancer prevention

III. Reproductive System Effects

A. Ovary

B. Uterus

C. Vagina

D. Neuroendocrine

IV. Skeletal Effects: Bone Mass, Bone Metabolism, and Fracture Occurrence

A. Tamoxifen

B. Raloxifene

V. Vascular System Effects: Intermediate Markers and Disease Outcomes

A. Intermediate markers

B. Vascular disease outcomes

VI. Central Nervous System Effects

A. Cognitive function and mood

B. Eye disease

VII. Hepatic Effects

VIII. Miscellaneous Effects

IX. Conclusion