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Molecular Control of Immune/Inflammatory Responses: Interactions Between Nuclear Factor-B and Steroid Receptor-Signaling Pathways

Laboratory of Signal Transduction, Molecular Endocrinology Group, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709

I. Introduction

II. Nuclear Factor-B (NF-B)

A. Introduction

B. NF-B is a dimeric transcription factor

C. The regulatory subunit IB is an inhibitor of NF-B

D. Activation and function of NF-B

E. The transcription factor NF-B interacts with multiple transcription factors and transcriptional co-factors

F. Transgenic animals suggest a complex role for NF-B family members in immunity and development

III. Steroid Hormones/Receptors: Glucocorticoids and the Glucocorticoid Receptor (GR)

A. General background

B. Glucocorticoid mechanism of action: the GR

C. Glucocorticoid physiology

D. GR/NF-B interactions

E. GR interacts with other transcription factors and transcriptional cofactors

IV. NF-B and GR Antagonism: Physiological Significance?

V. Interactions Between NF-B and Other Steroid Hormone Receptors

A. Androgen receptor (AR)

B. Estrogen receptor (ER)

C. Progesterone receptor (PR)

VI. Summary/Conclusions