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Peroxisome Proliferator-Activated Receptors: Nuclear Control of Metabolism¹

Institute of Animal Biology, University of Lausanne, CH-1015 Lausanne, Switzerland

I. Introduction

II. Molecular Aspects

A. PPAR isotypes: identity, genomic organization and chromosomal localization

B. DNA binding properties

C. PPAR ligand-binding properties

D. Alternative pathways for PPAR activation

E. PPAR-mediated transactivation properties

III. Physiological Aspects

A. Differential expression of PPAR mRNAs

B. PPAR target genes and functions in fatty acid metabolism

C. PPARs and control of inflammatory responses

D. PPARs and atherosclerosis

E. PPARs and the development of the fetal epidermal permeability barrier

F. PPARs, carcinogenesis, and control of the cell cycle

IV. Conclusions