This Article Full Text Full Text (PDF) Purchase Article View Shopping Cart Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Copyright Permission Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Hwa, V. Articles by Rosenfeld, R. G. Search for Related Content PubMed PubMed Citation Articles by Hwa, V. Articles by Rosenfeld, R. G.

The Insulin-Like Growth Factor-Binding Protein (IGFBP) Superfamily¹

Department of Pediatrics, Oregon Health Sciences University, Portland, Oregon 97201

I. Introduction

A. Concept of an IGFBP superfamily

B. Superfamily nomenclature

II. IGFBP Family

A. Structure of IGFBPs

B. Correlations between structure and function

C. Biological functions of IGFBPs

D. Genomics of IGFBPs

III. Mac25

A. IGFBP-rP1 (Mac25/TAF/PSF)

IV. CCN Family

A. IGFBP-rP2 (CTGF)

B. IGFBP-rP3 (NovH)

C. IGFBP-rP4 (Cyr61)

D. New members

V. L56

A. IGFBP-rP5 (L56/HtrA)

VI. ESM-1

A. IGFBP-rP6 (endothelial specific molecule-1)

VII. Structural Relationships Within the IGFBP Superfamily

A. Protein domains (modules)

B. Gene structure and correlation with protein domains

VIII. Functional Relationships Within the IGFBP Superfamily

A. IGF binding

B. Insulin binding

C. IGF/insulin-independent actions

IX. Evolutionary Relationships Within the IGFBP Superfamily

A. N-terminal domains

B. C-terminal domains

C. Evolutionary models

X. Summary