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Endocrine Reviews 23 (2): 141-174
Copyright © 2002 by The Endocrine Society

The Lutropin/Choriogonadotropin Receptor, A 2002 Perspective

Mario Ascoli, Francesca Fanelli and Deborah L. Segaloff

Departments of Pharmacology (M.A.) and Physiology and Biophysics (D.L.S.), The University of Iowa, Iowa City, Iowa 52242-1109; and Dipartimento di Chimica (F.F.), Universitá di Modena e Reggio Emilia, Via Campi 183 41100 Modena, Italy

Correspondence: Address all correspondence and requests for reprints to: Dr. Mario Ascoli, Department of Pharmacology, The University of Iowa, 2-319B BSB, 51 Newton Road, Iowa City, Iowa 52242-1109. E-mail: mario-ascoli{at}uiowa.edu

Reproduction cannot take place without the proper functioning of the lutropin/choriogonadotropin receptor (LHR). When the LHR does not work properly, ovulation does not occur in females and Leydig cells do not develop normally in the male. Also, because the LHR is essential for sustaining the elevated levels of progesterone needed to maintain pregnancy during the first trimester, disruptions in the functions of the LHR during pregnancy have catastrophic consequences. As such, a full understanding of the biology of the LHR is essential to the survival of our species. In this review we summarize our current knowledge of the structure, functions, and regulation of this important receptor.




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