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*Genetics Home Reference
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*Prostate Cancer
Endocrine Reviews 25 (2): 276-308
Copyright © 2004 by The Endocrine Society

Androgen Receptor in Prostate Cancer

Cynthia A. Heinlein and Chawnshang Chang

George Whipple Laboratory for Cancer Research, Departments of Pathology, Urology, and Radiation Oncology, and the Cancer Center, University of Rochester, Rochester, New York 14642

Correspondence: Address all correspondence and requests for reprints to: Chawnshang Chang, Ph.D., Department of Pathology, University of Rochester Medical Center, 601 Elmwood Avenue, Rochester, New York 14642. E-mail: chang{at}urmc.rochester.edu

The normal development and maintenance of the prostate is dependent on androgen acting through the androgen receptor (AR). AR remains important in the development and progression of prostate cancer. AR expression is maintained throughout prostate cancer progression, and the majority of androgen-independent or hormone refractory prostate cancers express AR. Mutation of AR, especially mutations that result in a relaxation of AR ligand specificity, may contribute to the progression of prostate cancer and the failure of endocrine therapy by allowing AR transcriptional activation in response to antiandrogens or other endogenous hormones. Similarly, alterations in the relative expression of AR coregulators have been found to occur with prostate cancer progression and may contribute to differences in AR ligand specificity or transcriptional activity. Prostate cancer progression is also associated with increased growth factor production and an altered response to growth factors by prostate cancer cells. The kinase signal transduction cascades initiated by mitogenic growth factors modulate the transcriptional activity of AR and the interaction between AR and AR coactivators. The inhibition of AR activity through mechanisms in addition to androgen ablation, such as modulation of signal transduction pathways, may delay prostate cancer progression.




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Home page
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Home page
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Home page
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Home page
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Herbal/Hormonal Dietary Supplement Possibly Associated with Prostate Cancer Progression
Clin. Cancer Res., January 15, 2008; 14(2): 607 - 611.
[Abstract] [Full Text] [PDF]

Home page
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[Abstract] [Full Text] [PDF]

Home page
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[Abstract] [Full Text] [PDF]

Home page
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Home page
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[Abstract] [Full Text] [PDF]

Home page
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H. Zong, Y. Chi, Y. Wang, Y. Yang, L. Zhang, H. Chen, J. Jiang, Z. Li, Y. Hong, H. Wang, et al.
Cyclin D3/CDK11p58 Complex Is Involved in the Repression of Androgen Receptor
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[Abstract] [Full Text] [PDF]

Home page
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[Abstract] [Full Text] [PDF]

Home page
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E. Estebanez-Perpina, L. A. Arnold, P. Nguyen, E. D. Rodrigues, E. Mar, R. Bateman, P. Pallai, K. M. Shokat, J. D. Baxter, R. K. Guy, et al.
A surface on the androgen receptor that allosterically regulates coactivator binding
PNAS, October 9, 2007; 104(41): 16074 - 16079.
[Abstract] [Full Text] [PDF]

Home page
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H. R. Qin, D. Iliopoulos, T. Nakamura, S. Costinean, S. Volinia, T. Druck, J. Sun, H. Okumura, and K. Huebner
Wwox Suppresses Prostate Cancer Cell Growth through Modulation of ErbB2-Mediated Androgen Receptor Signaling
Mol. Cancer Res., September 1, 2007; 5(9): 957 - 965.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
S. Lindstrom, H.-O. Adami, K. A. Balter, J. Xu, S. L. Zheng, P. Stattin, H. Gronberg, and F. Wiklund
Inherited Variation in Hormone-Regulating Genes and Prostate Cancer Survival
Clin. Cancer Res., September 1, 2007; 13(17): 5156 - 5161.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Endocrinol.Home page
Y. Dai, D. Ngo, L. W. Forman, D. C. Qin, J. Jacob, and D. V. Faller
Sirtuin 1 Is Required for Antagonist-Induced Transcriptional Repression of Androgen-Responsive Genes by the Androgen Receptor
Mol. Endocrinol., August 1, 2007; 21(8): 1807 - 1821.
[Abstract] [Full Text] [PDF]

Home page
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N. Sharifi, E. Hamel, M. A. Lill, P. Risbood, C. T. Kane Jr., M. T. Hossain, A. Jones, J. T. Dalton, and W. L. Farrar
A bifunctional colchicinoid that binds to the androgen receptor
Mol. Cancer Ther., August 1, 2007; 6(8): 2328 - 2336.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
Y. Li, Z. Wang, D. Kong, S. Murthy, Q. P. Dou, S. Sheng, G. P. V. Reddy, and F. H. Sarkar
Regulation of FOXO3a/beta-Catenin/GSK-3beta Signaling by 3,3'-Diindolylmethane Contributes to Inhibition of Cell Proliferation and Induction of Apoptosis in Prostate Cancer Cells
J. Biol. Chem., July 20, 2007; 282(29): 21542 - 21550.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
M. M. Shen and C. Abate-Shen
Pten Inactivation and the Emergence of Androgen-Independent Prostate Cancer
Cancer Res., July 15, 2007; 67(14): 6535 - 6538.
[Abstract] [Full Text] [PDF]

Home page
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A novel synthetic compound that interrupts androgen receptor signaling in human prostate cancer cells
Mol. Cancer Ther., July 1, 2007; 6(7): 2057 - 2064.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Pharmacol.Home page
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Vasoactive Intestinal Peptide Transactivates the Androgen Receptor through a Protein Kinase A-Dependent Extracellular Signal-Regulated Kinase Pathway in Prostate Cancer LNCaP Cells
Mol. Pharmacol., July 1, 2007; 72(1): 73 - 85.
[Abstract] [Full Text] [PDF]

Home page
 J. Histochem. Cytochem.Home page
H. Nakauchi, K.-i. Matsuda, I. Ochiai, A. Kawauchi, Y. Mizutani, T. Miki, and M. Kawata
A Differential Ligand-mediated Response of Green Fluorescent Protein-tagged Androgen Receptor in Living Prostate Cancer and Non-prostate Cancer Cell Lines
J. Histochem. Cytochem., June 1, 2007; 55(6): 535 - 544.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
T. I. Klokk, A. Kilander, Z. Xi, H. Waehre, B. Risberg, H. E. Danielsen, and F. Saatcioglu
Kallikrein 4 Is a Proliferative Factor that Is Overexpressed in Prostate Cancer
Cancer Res., June 1, 2007; 67(11): 5221 - 5230.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
J. E. Tillman, J. Yuan, G. Gu, L. Fazli, R. Ghosh, A. S. Flynt, M. Gleave, P. S. Rennie, and S. Kasper
DJ-1 Binds Androgen Receptor Directly and Mediates Its Activity in Hormonally Treated Prostate Cancer Cells
Cancer Res., May 15, 2007; 67(10): 4630 - 4637.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
G. Gu, J. Yuan, M. Wills, and S. Kasper
Prostate Cancer Cells with Stem Cell Characteristics Reconstitute the Original Human Tumor In vivo
Cancer Res., May 15, 2007; 67(10): 4807 - 4815.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
U. Simanainen, C. M. Allan, P. Lim, S. McPherson, M. Jimenez, J. D. Zajac, R. A. Davey, and D. J. Handelsman
Disruption of Prostate Epithelial Androgen Receptor Impedes Prostate Lobe-Specific Growth and Function
Endocrinology, May 1, 2007; 148(5): 2264 - 2272.
[Abstract] [Full Text] [PDF]

Home page
 JNCI J Natl Cancer InstHome page
H. Miyamoto, Z. Yang, Y.-T. Chen, H. Ishiguro, H. Uemura, Y. Kubota, Y. Nagashima, Y.-J. Chang, Y.-C. Hu, M.-Y. Tsai, et al.
Promotion of Bladder Cancer Development and Progression by Androgen Receptor Signals
J Natl Cancer Inst, April 4, 2007; 99(7): 558 - 568.
[Abstract] [Full Text] [PDF]

Home page
 Molecular Cancer TherapeuticsHome page
J. Guo, C. Jiang, Z. Wang, H.-J. Lee, H. Hu, B. Malewicz, H.-J. Lee, J.-H. Lee, N.-I. Baek, J.-H. Jeong, et al.
A novel class of pyranocoumarin anti-androgen receptor signaling compounds
Mol. Cancer Ther., March 1, 2007; 6(3): 907 - 917.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
C.-M. Chiu, S.-H. Yeh, P.-J. Chen, T.-J. Kuo, C.-J. Chang, P.-J. Chen, W.-J. Yang, and D.-S. Chen
Inaugural Article: Hepatitis B virus X protein enhances androgen receptor-responsive gene expression depending on androgen level
PNAS, February 20, 2007; 104(8): 2571 - 2578.
[Abstract] [Full Text] [PDF]

Home page
 J Mol EndocrinolHome page
L. Bonaccorsi, D. Nosi, M. Muratori, L. Formigli, G. Forti, and E. Baldi
Altered endocytosis of epidermal growth factor receptor in androgen receptor positive prostate cancer cell lines
J. Mol. Endocrinol., January 1, 2007; 38(1): 51 - 66.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
S. Srinivasan, R. S. Ranga, R. Burikhanov, S.-S. Han, and D. Chendil
Par-4-Dependent Apoptosis by the Dietary Compound Withaferin A in Prostate Cancer Cells
Cancer Res., January 1, 2007; 67(1): 246 - 253.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
R.-S. Wang, S. Yeh, L.-M. Chen, H.-Y. Lin, C. Zhang, J. Ni, C.-C. Wu, P. A. di Sant'Agnese, K. L. deMesy-Bentley, C.-R. Tzeng, et al.
Androgen Receptor in Sertoli Cell Is Essential for Germ Cell Nursery and Junctional Complex Formation in Mouse Testes
Endocrinology, December 1, 2006; 147(12): 5624 - 5633.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
C. Zhang, S. Yeh, Y.-T. Chen, C.-C. Wu, K.-H. Chuang, H.-Y. Lin, R.-S. Wang, Y.-J. Chang, C. Mendis-Handagama, L. Hu, et al.
Oligozoospermia with normal fertility in male mice lacking the androgen receptor in testis peritubular myoid cells
PNAS, November 21, 2006; 103(47): 17718 - 17723.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
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Imaging Mitogen-Activated Protein Kinase Function in Xenograft Models of Prostate Cancer.
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