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First published online on February 21, 2008
This version published online on May 12, 2008
Endocrine Reviews, doi:10.1210/er.2007-0031
A more recent version of this article appeared on May 1, 2008
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Submitted on September 10, 2007
Accepted on January 25, 2008

Targeting {beta}-Cell Mass in Type 2 Diabetes: Promise and Limitations of New Drugs Based on Incretins

Marzieh Salehi, Benedikt A. Aulinger, and David A. D'Alessio*

Department of Medicine, Division of Endocrinology, University of Cincinnati, Cincinnati, Ohio 45267-0547

* To whom correspondence should be addressed. E-mail: dalessd{at}ucmail.uc.edu.

Progressive insulin secretory defects, due to either functional abnormalities of the pancreatic {beta}-cells or a reduction in {beta}-cell mass, are the cornerstone of type 2 diabetes. Incretin-based drugs hold the potential to improve glucose tolerance by immediate favorable effect on {beta}-cell physiology as well as by expanding or at least maintaining {beta}-cell mass, which may delay the progression of the disease. Long-term studies in humans are needed to elaborate on these effects.






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