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The bibliographic list below is the second installment of the Genetically Modified Animals in Endocrinology database that is being compiled by Endocrine Reviews as a service to the research community. The first part appeared in the October 2001 issue (Endocr Rev 22:719–720, 2001) and listed citations describing the initial creation of knockout mice in the area of nuclear hormone receptors.
The list below gives citations describing the initial creation of genetically modified animals associated with the G proteins. In addition, citations of work in which significant use has been made of these animals are included. Because a significant part of the list involves nonmammalian species, these are included.
All sections will eventually be made available on a searchable Web site hosted by The Endocrine Society. Please send your comments, suggestions, and offerings of other relevant citations to this e-mail address: ERKO{at}endo-society.org
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G PROTEINS |
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 Top G PROTEINS I. MAMMALIANII. NONMAMMALIANRelated Web Sites |
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I. MAMMALIAN |
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TopG PROTEINSI. MAMMALIANII. NONMAMMALIANRelated Web Sites |
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i2) produced by gene targeting of both alleles. Proc Natl Acad Sci USA 88:7036–7040Mortensen RM, Seidman JG 1994 Inactivation of G-protein genes: double knockout in cell lines. Methods Enzymol 237:356–366[Medline]
Spiegel AM 1995 G protein gene knockout hits the gut. Nat Med 1:522–524[CrossRef][Medline]
Lendemann B 1996 Chemoreception: tasting the sweet and the bitter. Curr Biol 6:1234–1237[CrossRef][Medline]
Hornquist CE, Lu X, Rogers-Fani PM, Rudolph U, Shappell S, Birnbaumer L, Harriman GR 1997 G()i2-deficient mice with colitis exhibit a local increase in memory CD4+ T cells and proinflammatory Th1-type cytokines. J Immunol 158:1068–1077[Abstract]
Yu S, Yu D, Lee E, Eckhous M, Lee R, Corria Z, Accili D, Westphal H, Weinstein LS 1998 Variable and tissue-specific hormone resistance in heterotrimeric Gs protein -subunit (Gs) knockout mice is due to tissue-specific imprinting of the gs gene. Proc Natl Acad Sci USA 95:8715–8720
Tanaka M, Treloar H, Kalb RG, Greer CA, Strittmatter SM 1999 G(o) protein-dependent survival of primary accessory olfactory neurons. Proc Natl Acad Sci USA 96:14106–14111
Calvert PD, Krasnoperova NV, Lyubarsky AL, Isayama T, Nicolo M, Kosaras B, Wong G, Gannon KS, Margolskee RF, Sidman RL, Pugh Jr EN, Makino CL, Lem J 2000 Phototransduction in transgenic mice after targeted deletion of the rod transducin -subunit. Proc Natl Acad Sci USA 97:13913–13918 [Erratum in 2000 Proc Natl Acad Sci USA 98:10515]
Davignon I, Catalina MD, Smith D, Montgomery J, Swantek J, Croy J, Siegelman M, Wilkie TM 2000 Normal hematopoiesis and inflammatory responses despite discrete signaling defects in G15 knockout mice. Mol Cell Biol 20:797–804
Dhingra A, Lyubarsky A, Jiang M, Pugh Jr EN, Birnbaumer L, Sterling P, Vardi N 2000 The light response of ON bipolar neurons requires Go. J Neurosci 20:9053–9058
Greif GJ, Sodickson DL, Bean BP, Neer EJ, Mende U 2000 Altered regulation of potassium and calcium channels by GABA(B) and adenosine receptors in hippocampal neurons from mice lacking G(o). J Neurophysiol 83:1010–1018
Hendry IA, Kelleher KL, Bartlett SE, Leck KJ, Reynolds AJ, Heydon K, Mellick A, Megirian D, Matthaei KI 2000 Hypertolerance to morphine in G(z )-deficient mice. Brain Res 870:10–19[CrossRef][Medline]
Lyubarsky AL, Chen C, Simon MI, Pugh Jr EN 2000 Mice lacking G-protein receptor kinase 1 have profoundly slowed recovery of cone-driven retinal responses. J Neurosci 20:2209–2217
Nagata K, Ye C, Jain M, Milstone DS, Liao R, Mortensen RM 2000 G(i2) but not G(i3) is required for muscarinic inhibition of contractility and calcium currents in adult cardiomyocytes. Circ Res 87:903–909
Weinstein LS, Yu S, Ecelbarger CA 2000 Variable imprinting of the heterotrimeric G protein G(s) -subunit within different segments of the nephron. Am J Physiol Renal Physiol 278:F507–F514
Yang J, Wu J, Kowalska MA, Dalvi A, Prevost N, O’Brien PF, Manning D, Poncz M, Lucki I, Blendy JA, Brass LF 2000 Loss of signaling through the G protein, Gz, results in abnormal platelet activation and altered responses to psychoactive drugs. Proc Natl Acad Sci USA 97:9984–9989
Yu S, Gavrilova O, Chen H, Lee R, Liu J, Pacak K, Parlow AF, Quon MJ, Reitman ML, Weinstein LS 2000 Paternal versus maternal transmission of a stimulatory G-protein subunit knockout produces opposite effects on energy metabolism. J Clin Invest 105:615–623[Medline]
Chen F, Spicher K, Jiang M, Birnbaumer L, Wetzel GT 2001 Lack of muscarinic regulation of Ca(2+) channels in G(i2) gene knockout mouse hearts. Am J Physiol Heart Circ Physiol 280:H1989–H1995
Corvol JC, Studler JM, Schonn JS, Girault JA, Herve D 2001 G(olf) is necessary for coupling D1 and A2a receptors to adenylyl cyclase in the striatum. J Neurochem 76:1585–1588[CrossRef][Medline]
Dina OA, Aley KO, Isenberg W, Messing RP, Levine JD 2001 Sex hormones regulate the contribution of PKC
and PKA signaling in inflammatory pain in the rat. Eur J Neurosci 13:2227–2233[CrossRef][Medline]
Girkontaite I, Missy K, Sakk V, Harenberg A, Tedford K, Potzel T, Pfeffer K, Fischer KD 2001 Lsc is required for marginal zone B cells, regulation of lymphocyte motility and immune responses. Nat Immunol 2:855–862[CrossRef][Medline]
Jain M, Lim CC, Nagata K, Davis VM, Milstone DS, Liao R, Mortensen RM 2001 Targeted inactivation of G(i) does not alter cardiac function or ß-adrenergic sensitivity. Am J Physiol Heart Circ Physiol 280:H569–H575
Jantzen HM, Milstone DS, Gousset L, Conley PB, Mortensen RM 2001 Impaired activation of murine platelets lacking G (i2). J Clin Invest 108:477–483[CrossRef][Medline]
Kleppisch T, Voigt V, Allmann R, Offermanns S 2001 G()q-deficient mice lack metabotropic glutamate receptor-dependent long-term depression but show normal long-term potentiation in the hippocampal CA1 region. J Neurosci 15:4943–4948[Abstract]
Lania A, Mantovani G, Spada A 2001 G protein mutations in endocrine diseases. Eur J Endocr 145:543–559[Abstract]
Nieswandt B, Bergmeier W, Eckly A, Schulte V, Ohlmann P, Cazenave JP, Zirngibl H, Offermanns S, Gachet C 2001 Evidence for cross-talk between glycoprotein VI and Gi-coupled receptors during collagen-induced platelet aggregation. Blood 97:3829–3835
Serikov VB, Petrashevskaya NN, Canning AM, Schwartz A 2001 Reduction of [Ca(2+)](i) restores uncoupled ß-adrenergic signaling in isolated perfused transgenic mouse hearts. Circ Res 88:9–11
Yu S, Castle A, Chen M, Lee R, Takeda K, Weinstein LS 2001 Increased insulin sensitivity in Gs knockout mice. J Biol Chem 276:19994–19998
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II. NONMAMMALIAN |
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TopG PROTEINSI. MAMMALIANII. NONMAMMALIANRelated Web Sites |
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protein ODR-3 mediates olfactory and nociceptive function and controls cilium morphogenesis in C. elegans olfactory neurons. Neuron 20:55–67[CrossRef][Medline]
Chase DL, Patikoglou GA, Koelle MR 2001 Two RGS proteins that inhibit G(o) and G(q) signaling in C. elegans neurons require a Gß(5)-like subunit for function. Curr Biol 11:222–231[CrossRef][Medline]
Darby C, Falkow S 2001 Mimicry of a G protein mutation by pertussis toxin expression in transgenic Caenorhabditis elegans. Infect Immun 69:6271–6275
B. Dictyostelium discoideum
Kumagai A, Hadwiger JA, Pupillo M, Firtel RA 1991 Molecular genetic analysis of two G protein subunits in Dictyostelium. J Biol Chem 266:1220–1228
Hadwiger JA, Firtel RA 1992 Analysis of G 4, a G-protein subunit required for multicellular development in Dictyostelium. Genes Dev 6:38–49
Okaichi K, Cubitt AB, Pitt GS, Firtel RA 1992 Amino acid substitutions in the Dictyostelium G subunit G 2 produce dominant negative phenotypes and inhibit the activation of adenylyl cyclase, guanylyl cyclase, and phospholipase C. Mol Biol Cell 3:735–747[Abstract]
Chen MY, Devreotes PN, Gundersen RE 1994 Serine 113 is the site of receptor-mediated phosphorylation of the Dictyostelium G protein -subunit G 2. J Biol Chem 269:20925–20930
Devreotes PN 1994 G protein-linked signaling pathways control the developmental program of Dictyostelium. Neuron 12:235–241[CrossRef][Medline]
Dharmawardhane S, Cubitt AB, Clark AM, Firtel RA 1994 Regulatory role of the G 1 subunit in controlling cellular morphogenesis in Dictyostelium. Development 120:3549–3561[Abstract]
Schnitzler GR, Briscoe C, Brown JM, Firtel RA 1995 Serpentine cAMP receptors may act through a G protein-independent pathway to induce postaggregative development in Dictyostelium. Cell 81:737–745[CrossRef][Medline]
Van Haastert PJ 1995 Transduction of the chemotactic cAMP signal across the plasma membrane of Dictyostelium cells. Experientia 51:1144–1154[CrossRef][Medline]
Wu L, Valkema R, Van Haastert PJ, Devreotes PN 1995 The G protein ß subunit is essential for multiple responses to chemoattractants in Dictyostelium. J Cell Biol 129:1667–1675
Hadwiger JA, Natarajan K, Firtel RA 1996 Mutations in the Dictyostelium heterotrimeric G protein subunit G5 alter the kinetics of tip morphogenesis. Development 122:1215–1224[Abstract]
van Es S, Weening KE, Devreotes PN 2001 The protein kinase YakA regulates g-protein-linked signaling responses during growth and development of Dictyostelium. J Biol Chem 276:30761–30765
C. Flies
Brault V, Sauder U, Reedy MC, Aebi U, Schoenenberger CA 1999 Differential epitope tagging of actin in transformed Drosophilaproduces distinct effects on myofibril assembly and function of the indirect flight muscle. Mol Biol Cell 10:135–149
Eriksen KK, Hauser F, Schiott M, Pedersen KM, Sondergaard L, Grimmelikhuijzen CJ 2000 Molecular cloning, genomic organization, developmental regulation, and a knock-out mutant of a novel leu-rich repeats-containing G protein-coupled receptor (DLGR-2) from Drosophila melanogaster. Genome Res 10:924–938
Guo HF, Tong J, Hannan F, Luo L, Zhong Y 2000 A neurofibromatosis-1-regulated pathway is required for learning in Drosophila. Nature 403:895–898[CrossRef][Medline]
Huber A, Belusic G, Da Silva N, Bahner M, Gerdon G, Draslar K, Paulsen R 2000 The Calliphorarpa mutant lacks the PDZ domain-assembled INAD signaling complex. Eur J Neurosci 12:3909–3918[CrossRef][Medline]
Decoville M, Giacomello E, Leng M, Locker D 2001 DSP1, an HMG-like protein, is involved in the regulation of homeotic genes. Genetics 157:237–244
D. Plants
McNellis TW, von Arnim AG, Araki T, Komeda Y, Misera S, Deng XW 1994 Genetic and molecular analysis of an allelic series of cop1 mutants suggests functional roles for the multiple protein domains. Plant Cell 6:487–500[Abstract]
Ullah H, Chen JG, Young JC, Im KH, Sussman MR, Jones AM 2001 Modulation of cell proliferation by heterotrimeric G protein in Arabidopsis. Science 292:2066–2069
E. Yeasts
Cole GM, Stone DE, Reed SI 1990 Stoichiometry of G protein subunits affects the Saccharomyces cerevisiae mating pheromone signal transduction pathway. Mol Cell Biol 10:510–517
Kang YS, Kane J, Kurjan J, Stadel JM, Tipper DJ 1990 Effects of expression of mammalian G and hybrid mammalian-yeast G proteins on the yeast pheromone response signal transduction pathway. Mol Cell Biol 10:2582–2590
Hirsch JP, Dietzel C, Kurjan J 1991 The carboxyl terminus of Scg1, the G subunit involved in yeast mating, is implicated in interactions with the pheromone receptors. Genes Dev 5:467–474
Kurjan J, Hirsch JP, Dietzel C 1991 Mutations in the guanine nucleotide-binding domains of a yeast G protein confer a constitutive or uninducible state to the pheromone response pathway. Genes Dev 5:475–483
Isshiki T, Mochizuki N, Maeda T, Yamamoto M 1992 Characterization of a fission yeast gene, gpa2, that encodes a G subunit involved in the monitoring of nutrition. Genes Dev 6:2455–2462
Hirsch JP, Cross FR 1993 The pheromone receptors inhibit the pheromone response pathway in Saccharomyces cerevisiae by a process that is independent of their associated G protein. Genetics 135:943–953[Abstract]
Fabry S, Steigerwald R, Bernklau C, Dietmaier W, Schmitt R 1995 Structure-function analysis of small G proteins from Volvox and Chlamydomonas by complementation of Saccharomyces cerevisiae YPT/SEC mutations. Mol Gen Genet 247:265–274[CrossRef][Medline]
Spain BH, Koo D, Ramakrishnan M, Dzudzor B, Colicelli J 1995 Truncated forms of a novel yeast protein suppress the lethality of a G protein subunit deficiency by interacting with the ß subunit. J Biol Chem 270:25435–25444
Yu Y, Hirsch JP 1995 An essential gene pair in Saccharomyces cerevisiae with a potential role in mating. DNA Cell Biol 14:411–18[Medline]
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TopG PROTEINSI. MAMMALIANII. NONMAMMALIANRelated Web Sites |
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http://www-insel.ucsd.edu/gpcr00.htm
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