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Endocrine Reviews 20 (5): 649
Copyright © 1999 by The Endocrine Society

Peroxisome Proliferator-Activated Receptors: Nuclear Control of Metabolism1

Béatrice Desvergne and Walter Wahli

Institute of Animal Biology, University of Lausanne, CH-1015 Lausanne, Switzerland

I. Introduction
II. Molecular Aspects
A. PPAR isotypes: identity, genomic organization and chromosomal localization
B. DNA binding properties
C. PPAR ligand-binding properties
D. Alternative pathways for PPAR activation
E. PPAR-mediated transactivation properties
III. Physiological Aspects
A. Differential expression of PPAR mRNAs
B. PPAR target genes and functions in fatty acid metabolism
C. PPARs and control of inflammatory responses
D. PPARs and atherosclerosis
E. PPARs and the development of the fetal epidermal permeability barrier
F. PPARs, carcinogenesis, and control of the cell cycle
IV. Conclusions




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Home page
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Home page
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Home page
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[Abstract] [Full Text] [PDF]

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[Abstract] [PDF]

Home page
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[Abstract] [Full Text] [PDF]

Home page
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[Abstract] [Full Text] [PDF]

Home page
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[Abstract] [Full Text] [PDF]

Home page
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[Abstract] [Full Text] [PDF]

Home page
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[Abstract] [Full Text] [PDF]

Home page
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[Abstract] [Full Text] [PDF]

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Home page
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[Abstract] [Full Text] [PDF]

Home page
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[Abstract] [Full Text] [PDF]

Home page
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Home page
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Home page
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Home page
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Home page
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Home page
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Home page
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Home page
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L. Michalik, V. Zoete, G. Krey, A. Grosdidier, L. Gelman, P. Chodanowski, J. N. Feige, B. Desvergne, W. Wahli, and O. Michielin
Combined Simulation and Mutagenesis Analyses Reveal the Involvement of Key Residues for Peroxisome Proliferator-activated Receptor{alpha} Helix 12 Dynamic Behavior
J. Biol. Chem., March 30, 2007; 282(13): 9666 - 9677.
[Abstract] [Full Text] [PDF]