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First published online on November 29, 2007
Endocrine Reviews, doi:10.1210/er.2007-0033
A more recent version of this article appeared on May 1, 2008
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Cytokines and {beta}-Cell Biology: from Concept to Clinical Translation

Marc Y. Donath, Joachim Størling, Lukas A. Berchtold, Nils Billestrup, and Thomas Mandrup-Poulsen*

The Clinic for Endocrinology and Diabetes, University Hospital Zurich, Zurich, Switzerland; Department for Translational Diabetology, Steno Diabetes Center, Gentofte, Denmark; and Core Unit for Medical Research Methodology, Institute of Biomedicine, Faculty of Health Sciences, University of Copenhagen, Denmark

* To whom correspondence should be addressed. E-mail: tmpo{at}steno.dk.

The tale of cytokines and the {beta}-cell is a long story, starting with in vitro discovery in 1984, evolving via descriptive and phenomenological studies to detailed mapping of the signalling pathways, gene- and protein expression patterns, molecular and biochemical effector mechanisms to in vivo studies in spontaneously diabetic and transgenic animal models. Only very recently have steps been taken to translate the accumulating compelling preclinical data into clinical trials. The aim of this chapter is to present an overview of early and recent key observations from our own groups as well as other laboratories that serve to illuminate the road from concept to clinical translation.




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